| abstract |
Disclosed are 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure:n wherein: R 1 , R 2 , R 6 , R 7 and R 8 are, inter alia, independently selected from the group consisting of hydrogen (R' and R 2 are not hydrogen), alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds. |