| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d3b01fb021788dbfc32162e3ac5a12c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate |
1980-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76cb0d396344b921182a89f9347cb80f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_287889f9da458afb913085a2bd9ae230
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32e61fc60b9295ee57aa928845db44a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68dbe202d83bc423bb410b7993294792 |
| publicationDate |
1981-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0029247-A1 |
| titleOfInvention |
Alkenyl thienyl alkane carboxylic acids and their derivatives, process for their preparation and medicaments containing them |
| abstract |
There are ω- (5-alkenylthien-2-yl) alkanecarboxylic acids and their derivatives of the general formula I: <IMAGE> in which n is an integer from 1 to 9, R¹ is hydrogen and R² is a hydroxyl group, or R¹ and R² together represent a double-bonded oxygen atom, R³ is hydrogen, alkali ion or a straight-chain or branched saturated hydrocarbon group with 1-6 carbon atoms, which have anti-inflammatory properties without irritating effects on the gastric mucosa. They can be prepared starting from compounds of the general formula II <IMAGE> by reacting these compounds in an organic solvent with a 2-oxoheptylphosphonic acid dialkyl ester in the presence of a base and optionally saponifying the ester group in a solvent by reaction with alkali metal hydroxides and then the free acids by adding mineral acid. The keto compounds in question, in which R 1 and R 2 of the formula I together represent a double-bonded oxygen atom, can be converted into the corresponding hydroxyl compound by reducing agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0319900-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0319900-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0161904-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8805045-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0155524-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2574794-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5116981-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0161904-A2 |
| priorityDate |
1979-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |