http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0028627-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-57581 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate | 1980-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1984-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0028627-B1 |
| titleOfInvention | Process for producing polypeptide alpha-thymosine and derivatives therefrom |
| abstract | With a view to preparing (Alpha)-thymosine or a derivative thereof, different in that at least an amino acid remainder in the position 10, 15, 21, 25 and 28 of the sequence has an amid or alkyl-amid group and/or in that the acetyl group is substituted by another acyl group or with a view to preparing fragments of such polypeptide, a) a C-terminal fragment of the polypeptide is condensated, and has an N-terminal group non protected and a C-terminal group esterified or bound to a carrier molecule, in a quantity stoechiometrically lower of at least 1.5 times, with a fragment close to the polypeptide, fragment which is protected at its N-terminal end by a Ddz group and which has a non protected C-terminal end; this condensation is carried out in a dry organic solvent medium with, as a condensation agent, dicyclohexylcarbodiimide and 1-hydroxybenzotriazol, b) the remainder Ddz, protector group of the condensed fragment, is eliminated by addition of trifluoroacetic acid in a quantity slightly higher than the stoechiometry, c) the excess of acid is neutralized by means of an organic base and d) the C-terminal prolonged fragment of the polypeptide is condensed, fragment which is obtained by said condensation method and which has a non protected N-terminal end, with the neighbouring fragment in the sequence of the polypeptide, fragment which is protected in the N-terminal end by a Ddz group; this condensation is carried out by repetition of the steps a), b) and c) as long as it is necessary with a view to obtaining the complete sequence of the polypeptide in question. Thereafter, the remaining protector groups are continuously eliminated; have being used as protector groups in the lateral chains, for Asp and Glu, T-butylester groups for Ser and Thr, t-butyl groups, for Lys, benzyloxycarbonyl groups and for Asn, 4, 4'-dimethoxybenzhydryl groups; if necessary, the acetyl group at the N-terminal end will be changed for an other acyl group. |
| priorityDate | 1979-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.