| abstract |
Phosphorylmuramyl peptides of the formula <IMAGE> are immunopotentiating. In the formula R1 is optionally substituted alkyl or aryl, R2, R4, R6 and R7 e.g. Hydrogen, R3 hydrogen or lower alkyl R5 e.g. Hydrogen, lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl or aralkyl, nitrogen-containing heterocyclyl or heterocyclyl-lower alkyl and one of the radicals A1 and A2 is a radical of the formula (II). <IMAGE> In formula (II), T represents NH or O, Y represents an optionally substituted alkylene group, which can also be interrupted by one or two oxycarbonyl and / or iminocarbonyl, and W represents an aliphatic radical or a cycloalkyl or cycloalkeny radical with more than 6 carbon atoms. The other of the radicals A1 and A2 stands for free or etherified hydroxy, amino, lower alkylamino or aminocarbonyl-lower alkylamino. |