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filingDate 1980-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1983-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0027161-B1
titleOfInvention Insulin derivatives, process for their preparation and their use
abstract 1. Claims for the Contracting States : BE, CH, LI, DE, FR, GB, IT, NL, SE Insulin derivative wherein the amino group of the B1-phenylalanine is linked to the free OH group of a monoalkylpolyethyleneglycol via a low molecular radical connecting member. 1. Claims for Contracting State : AT A process for the preparation of an insulin derivative wherein the alpha-amino group of the insulin B-chain is linked to a monoalkylpolyethyleneglycol via a connecting member, which process comprises reacting an insulin containing protecting groups in the N**alpha A1 and N**epsilon B29 positions with an alkyl-polyethyleneglycol derivative and subsequently splitting off the protecting groups.
priorityDate 1979-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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