| abstract |
Known and novel compounds of formula (I) …<CHEM>… wherein E is a sulphur atom or a NH or CH2 group, J is a nitrogen atom or a CH group, Q is a sulphur atom or a NR<3> or CHR<3> group, Z is oxygen or sulphur atom or a NR<4> or CHR<4> group and R<1> represents four substituents and R<2> represents five substituents, provided at least three of E, J, Q and Z are methylene residues, are active against viruses, especially rhinoviruses. Methods for producing the compounds are described, as are pharmaceutical formulations and methods for administering the compounds to cure or prevent rhinoviral infections. |