| abstract |
The invention relates to the preparation of syn, R is phenyl, thienyl, furyl, thiazolyl, optionally substituted by halogens, NH 2 , protected NH 2 , R 1 is H, a group protecting OH, alkyl, alkenyl, alkynyl, cycloalkyl, optionally substituted, acyl, R ' 2 is H, R 3 is H, alkyl, or R 3 is H, R ' 2 is halogen, alkyl, cycloalkyl, alkoxy, alkylthio, acetoxymethyl, carbamoyloxymethyl, -NH-CO-alkyl, CH 2 -SR 5 , R 5 is heterocycle (5.6 members), 1-4 heteroatoms (S, N, O) optionally substituted, acyl, condensed heterocycle or R ' 2 is azidomethyl -CH 2 A 'is H, alkaline, alkaline earth, Mg, ammonium, amino base ester, or COOA' is COO-, n is 0 to 2, process consisting in treating in a solvent, possibly in basic medium A, has the values of A ′ except ester, with R 4 SO 2 Hal, R 4 is alkyl, aryl, optionally substituted aralkyl, Hal is halogenated, then to be treated in a solvent, optionally in basic medium, the product obtained with The products are antibiotics. |