| abstract |
Imidazole cyanoguanidines of formula n<CHEM>n wheren R1 is hydrogen or methyl;n R2 is lower alkyl; each of m and n independently of the other, is 0, 1, 2, or 3;n A is a phenylene, cyclohexylene, thienylene, tetrahydrothienylene, or 1,3-dithianylene radical and is optionally substituted with a halogen;n Y is oxygen, sulfur, = NR3 or = CHR4 where R3 is hydrogen, cyano, lower alkyl, phenyl, lower alkylsulfonyl, or phenysulfonyl; andn R4 is nitro, phenylsulfonyl, or lower alkylsulfonyl, and their pharmaceutically acceptable salts, are novel and are useful for the suppression of gastric acid secretion in mammals. Compositions for such uses containing the compounds are also disclosed. The compounds are made by introducing the nnNHR2-@-group into an amine of formula n<CHEM> |