http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0019345-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a333e6344b62fb21a7c1ee592b165fca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1978-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8111513d3c6a5812efbee7b5c6aa8119 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21c904eed0af8868b17a2cc7d9396e52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_243314307c9f8e8ea324909ce7d8ecda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3309aa7ad9046f0ee16be8f1e026ea2 |
| publicationDate | 1980-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0019345-A1 |
| titleOfInvention | Process for the preparation of a (D-alpha-amino-(p-hydroxyphenyl)-acetamido) group containing cephalosporanic acid derivatives |
| abstract | Process for the preparation of [D-a-amino-(p- hydroxyphenyl)acetamido] groups containing cephalosporanic acid derivatives, comprising the acylation of a compound of the formulae:n wherein R,, R 2 and R 3 representthe same or a different group and may be selected from a lower alkyl, benzyl, cycloalkyl or. phenyl-group and preferably lower alkyl and more preferably a methyl group an wherein X represents a residue selected from the group consisting of hydrogen, acetoxy or a five-membered heterocyclic thio residue, containing heteroatoms selected from nitrogen, oxygen, and/or sulphur and optionally substituted by lower alkyl and wherein an eventually present -NH- radical has optionally been silylated, which compound is previously prepared by the reaction of 7-aminocephalosporanic acid or its 3-methyl modifications with at least one equivalent and preferably about two with respect to other 3-methyl modifications of 7-ACA of a tri(lower)alkyl silyl groups supplying agent in a dry, inert, water insoluble solvent, such as methylene chloride, by rapid mixing of a pre-cooled solution of the compound offormulae I and Il with a pre-cooled reaction mixture of at least an equimolecular amount of a compound of the formulan n wherein R 4 represents lower alkyl and preferably methyl, R 5 represents hydrogen or lower alkyl and preferably methyl, R 6 represents lower alkoxy and preferably methoxy, nand R 7 represents lower alkoxy and preferably methoxy, previously prepared from the corresponding Dane salt and an acid chloride under anhydrous conditions in the presence of a tertiary amine as catalyst, such as N-methylmorpholine in a dry, inert, water insoluble, organic solvent such as methylene chloride mixed with a co-solvent or methyl isobutylketone or tetrahydrofuran optionally mixed with a co-solvent, and the continuation of the reaction at a temperature of -10°C or lower and preferably from -20°C to -30°C whereafter the desired compound is recovered by usual methods. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2240102-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2240102-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-395854-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-396238-B |
| priorityDate | 1977-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 311.