http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0019115-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-595 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-065 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-595 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
filingDate | 1980-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35e6b4ea2fb5533bbc11e8c7ba6546d9 |
publicationDate | 1980-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0019115-A1 |
titleOfInvention | Pancreozymin-cholezystokinin active peptides, process for their preparation and pharmaceutical compositions containing them |
abstract | Peptides with the carboxyl-terminal sequence of pancreozymin cholecystokinin 25-33, such that amino acid residue 25 carries a strongly basic group, amino acid residue 28 has a hydrophilic character of the hydroxyamino acid type and amino acid residue 31 has a strongly hydrophobic character of the type of amino acids with aliphatic side chains has, in particular nonapeptides of the sequence HX-Asp-Tyr (S0 3 H) - Y-Gly-Trp-Z-Asp-Phe-NH 2 , where X is arginine, homoarginine, norarginine, Ne, N ε- dialkyllysine. N8 or Nδ-dialkylornithine, Y threonine, serine or hydroxy-proline and Z is norleucine, leucine, norvaline or a-aminobutyric acid, have pronounced pancreozymin activity and can be used in drugs for controlling the function of the gallbladder and for controlling the enzyme secretion of the Pancreas.n n n Tyrosine-O-sulphate-barium salt and its N-acyl derivatives can be used as intermediates for the preparation of such peptides to give 27, a N-acyl-tyrosine in a polar organic solvent, with excess pyridine-S0 3 is reacted to introduce the amino acid residue, the resulting Solution extracted with water, the barium salt of N-acyl-tyrosine-O-sulfate falls from the aqueous phase by adding a soluble barium compound, optionally splitting off the acyl group in the usual way and the tyrosine-O-sulfate-barium salt thus obtained or its acyl derivative processed in a manner known per se by customary peptide synthesis methods. |
priorityDate | 1979-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.