| abstract |
Disclosed are antibiotic cephalosporins (I) of the formula :n Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, -NR 2 , -OR, COOR, CONR 2 or CN; A is conventionally known in the cephalosporin art; and R 2 is H, or loweralkoxyl; X is S, 0, CH 2 , or NR 7 (R 7 is, interalia, hydrogen, alkyl or aralkyl. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of processes for the preparation of such compounds; and pharmaceutical compositions comprising such compounds. |