| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate |
1980-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d10dcf42d02fd17cf2b5f9fd5d1c3f0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a23320970dc771aadfe9e237ca30b387
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_610ca36dc6ac118277c46bf9ea3ac3d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d6e76efa95405b5561b09263a07f71a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcd736c86b3026e49623b0c0fa435c0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ca26004c3e55b27222d9f61af60ae67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_991323b10a9ce2db2f8a13aea6f1e505 |
| publicationDate |
1980-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0018231-A2 |
| titleOfInvention |
A process for the preparation of bis-indole-alkaloids and acid addition salts thereof and new bis-indole-alkaloids, pharmaceutical compositions containing them and their use as antitumour agents |
| abstract |
A proces for the oxidation of vinblastine, leurosine or an acid addition salt thereof which comprises reacting the vinblastine, leurosine or acid addition salt thereof with chromic acid or an alkali metal dichromate, at a temperature of from -30 °C to 90°C in the presence of a water immiscible organic solvent in which alkaloids are readily soluble, acetic anhydride and optionally glacial acetic acid and/or up to 10% by volume of ethanol based on the volume of the water-immiscible organic solvent; thereafter adjusting the pH of the reaction mixture to from 8 to 10; and isolating the products obtained and/or subjecting the said products to further treatment.The specification also describes new bis-indole-alkaloids, pharmaceutical compositions containing them and their use as anti-tumour agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0079785-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0037290-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0037289-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4490378-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0117861-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0079785-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3132475-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3132476-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4410459-A |
| priorityDate |
1979-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |