| abstract |
6-Substituted-arytpyrido[2,3-d]pyrimidin-7-amines and derivatives are disclosed which have the following formula:n wherein R, and R 2 are hydrogen or alkyl; R 4 is halogen or alkyl; R 5 and R 6 are hydrogen, haloaen or alkvl: R 3 is H 2 N-,n = N-, CH 3 -SO 2 -NH- or CH 3 -NH-C-NH-; R is hydrogen, alkyl, haloalkyl, alkoxy, alkoxymethylene, mono- or dialkylamino, trifluoromethyl, furyl, pyridyl or phenyl; R 7 is hydrogen or alkyl; and R s is hydrogen or alkylamino. n The foregoing compounds, and pharmaceutically acceptable acid addition salts, as well as pharmaceutical compositions containing such compounds or salts, are useful in the treatment of hypertension. Processes for producing the compounds are also disclosed. |