| abstract |
New arabinofuranosyl nucleosides and nucleotides with 2'-azido, 2'-amino or 2'-hydrocarbylamino substituents having antitumor, antiviral and antimicrobial properties are prepared by condensation of a pyrimidine, purine or 1,3 base -oxazine with a 2-azido-2-deoxyarabino-furanosyl acyl halide followed by a deblocking and a catalytic hydrogenation, if necessary, to convert the 2'-azido group into a 2'-amino group and, if desired , by alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group. |