http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0015810-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d0cb7734bc2e5840db630f0ae7c29684 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 |
filingDate | 1980-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_422607f6be34121b0ee7a7aa6bb578d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9f8b961ec9e321660b74361fc38c9db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81bbf36bb0084b4b79daba4379faf19c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef8b3f68be3986a0a6949f8ae243dc77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35c678273d6de573054e039053fe7303 |
publicationDate | 1980-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0015810-A1 |
titleOfInvention | N-Acetyl-L-(N-methyl-alanil)-D-isoglutamine and compositions containing it for use as regulator of the immune reactions |
abstract | X représentant un groupe alkyle de 1 à 4 atomes de carbone, Y est, soit -OH, soit un radical alcoxy comprenant de 1 à 10 atomes de carbone, soit un groupe -NH 2 , les hydrogènes du groupe amino pouvant être substitués par des restes alcoyle comprenant de 1 à 10 atomes de carbone, soit encore un reste d'acide aminé substitué ou non, Z est -OH, -NH 2 ou encore un radical alcoxy de 1 à 10 atome de carbone, R est soit un atome d-hydrogène, soit un groupe alcoyle comprenant de 1 à 4 atomes de carbone, R 1 est un atome d'hydrogène, R 2 est un atome d'hydrogène ou un groupe alcoyle, aryle ou alcoyl-aryle éventuellement substitué et comportant au plus 22 atomes de carbone, R 4 est un atome d-hydrogène ou un radical acyle comprenant au plus 4 atomes de carbone, R6 est un atome d'hydrogène, un groupe acyle saturé ou non, éventuellement ramifié, contenant de 1 à environ 90 atomes de carbone et pouvant, en outre, porter des groupes fonctionnels: hydroxyle, carboxyle, amino, cyclopropane, méthoxyle. The muramyl peptides according to the invention comprise at least two aminoacyl residues in the peptide chain, the second of these aminoacyls being D-glutamyl, and are characterized in that the nitrogen of the first aminoacyl, and forming part of the peptide bond connecting the muramyl group with the peptide residue, is substituted by an alkyl group. They respond to the formula: in which the substituents have the following meanings: is an amino acid residue by which Ra represents a group -CH 3 or -CH 2 OH, X representing an alkyl group of 1 to 4 carbon atoms, Y is either -OH or an alkoxy radical comprising from 1 to 10 carbon atoms or a group -NH 2 , the hydrogens of the amino group possibly being substituted by alkyl radicals comprising from 1 to 10 carbon atoms, or alternatively a residue of substituted or unsubstituted amino acid, Z is -OH, -NH 2 or an alkoxy radical of 1 to 10 carbon atoms, R is either a hydrogen atom or an alkyl group comprising from 1 to 4 carbon atoms, R 1 is a hydrogen atom, R 2 is a hydrogen atom or an optionally substituted alkyl, aryl or alkyl-aryl group containing at most 22 carbon atoms, R 4 is a hydrogen atom or an acyl radical comprising at most 4 carbon atoms, R6 is a hydrogen atom, a saturated or unsaturated acyl group, optionally branched, containing from 1 to about 90 carbon atoms and which can, in addition, carry functional groups: hydroxyl, carboxyl, amino, cyclopropane, methoxyl. n n n These compounds are useful in particular for the preparation of pharmaceutical compositions, in particular, because of their regulatory properties of the body's immune responses. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9310148-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-666890-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4457913-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0038750-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5506204-A |
priorityDate | 1979-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.