| abstract |
Octahydropyrazolo [3,4-g] quinolines of the general formula:whereinR is (C<sub>1-3</sub>)alkyl or allyl;R<sup>1</sup> is H or CH<sub>2</sub>X wherein X is OCH<sub>3</sub>, SCH<sub>3</sub>, CN, SO<sub>2</sub>CH<sub>3</sub> or CONH<sub>2</sub>; andpharmaceutically-acceptable acid addition salts thereof.These compounds, dopamine agonists, useful in treatment of Parkinsonism and in inhibiting secretion of prolactin, are prepared by reacting a corresponding 7-dimethylaminomethylene-6-oxo-derivative with hydrazine hydrate. |