| abstract |
There are disclosed novel 15-deoxy-16-hydroxy-16-substituted prostanoic acid analogs in which the C-1 carboxyl is replaced by a primary alcohol and carboxylic acid esters, carbonates and carbamates thereof, and which have utility as bronchodilators, as hypotensive agents, and as agents for the control of excessive gastric secretion. The novel compounds are represented by the formula: n<CHEM>n wherein Q is a divalent cyclopentyl moiety selected from the group consisting of: n<CHEM>n wherein R/ is an alkyl (C3-C7) optionally substituted with one or more alkyl groups of one to three carbon atoms; R2 is selected from the group hydroxyl, alkoxy, alkanoyloxy, a protecting group such as tetrahydropyran-2-yl-oxy, triloweralkylsilyloxy; or alkoxyalkoxy such as n<CHEM>n wherein R min is hydrogen or alkyl (C1-C4) and R sec is alkyl (C1-C4); X is the divalent radical n<CHEM>n wherein R3 is selected from the group vinyl and cyclopropyl; Z is selected from the group -(CH2)4, n<CHEM>n wherein R4 is selected from the group alkyl (C1-C4); alkoxy (C1-C4); dialkylamino (C1-C4); phenyl and phenyl substituted with one or more substituents selected from the group consisting of hydrogen, hydroxyl, lower alkyl, lower alkoxy, loweralkylthia, fluoride or chloride, wherein lower alkyl is C1-C4; The formula above embraces the optical isomers, racemic or |