| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F3-14 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F3-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 |
| filingDate |
1979-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a744850d4d91b1d9453871448ea9a546
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2664323b169efa1c73a9e577c279f9c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5602b5b313120cc4a512ec9e5946f88 |
| publicationDate |
1980-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0011373-A1 |
| titleOfInvention |
5-Oxo-5H-hexahydrofuro(3,2-b)pyrrole derivatives, their preparation, intermediates, and pharmaceutical compositions containing said derivatives |
| abstract |
The novel 5-oxo-5H-hexahydrofuro [3,2-b] pyrrole derivatives of formula (I):n wherein:n A is CH-and n is 1 to 6; or A is C=CH- and n is 0 to 5; or A is CH-CH=CH- and n is 0 to 4; and R 1 is hydrogen or C 1-6 alkyl; R 2 is hydrogen or C 1-6 alkyl; and R 3 is C 4-9 alkyl, C 5-7 cycloalkyl or C 5-7 cycloalkyl-C 1-6 alkyl; e.g. 2-(4'-ethoxycarbonyl-n-butyl)-4-(3' '-hydroxy-3' '-methyl-n-nonyl)- 5-oxo-5H-hexahydrofuro [3,2-b] pyrrole, and salts thereof, have antiplatelet aggregation and bronchodilation activity. They can be prepared by (I) demercuration, (II) dehydrohalogenation or (III) oxidation of a compound of formula (VI):n wherein R R 2 and R 3 are as defined above, p is 0 to 5 and X is (I) a mecuri salt, (II) halo or (III) phenyl selenyl respectively. The preparation of the compounds of formula (VI) is described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796093-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102796093-A |
| priorityDate |
1978-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |