http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0009683-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 1979-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1983-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0009683-B1 |
| titleOfInvention | Basic phenyl ethers, pharmaceutical compositions containing them and the preparation of these ethers and compositions |
| abstract | For the Contracting States : BE, CH, DE, FR, GB, IT, NL, SE 1. Basic ethers of the general formula I see diagramm : EP0009683,P12,F1 wherein G is an unsubstituted phenyl oder benzyl group or a phenyl or benzyl group which is monosubstituted or disubstituted by halogen or is alkyl with 1-6 C atoms, Z is 1-imidazolyl or 2-methyl-1-imidazolyl, A is -CH=CR**1-, -CO-CHR**1-, -CHOH-CHR**1- or -CH2 -CHR**2-, n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts. For the Contracting State : AT 1. Process for the preparation of basic ethers of the general formula I see diagramm : EP0009683,P13,F1 dans laquelle A is -CH=CR**1-, -CO-CHR**1, -CHOH-CHR**1- or -CH2 -CHR**2-. n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts, characterized in that a compound of the general formula II R-Q wherein R is the group C-O- see diagramm : EP0009683,P13,F2 and Q is a radical which can be reduced to a group -A-(CH2 )n -Z, and G, Z, A and n have the meaning indicated above, is treated with a reducing agent, or in that a compound which corresponds to the general formula I but in which the hydroxyl group is present in a functionally modified form is treated with a solvolyzing agent with liberation of the hydroxyl group, or in that a compound of the general formula III R-A-(CH2 )n -X wherein X is Cl, Br, I, OH or reactively functionally modified OH and R, A and n have the meaning indicated above, is reacted with a compound of the general H-Z and in that, optionally, a resulting hydroxy compound of the formula I wherein A is -CHOH-CHR**1- is treated with a dehydrating agent and/or a resulting compound of the formula I wherein A is -CH=CR**1-, CO-CHR**1- or -CHOH-CHR**1 is treated with a reducing agent and/or a resulting base of the formula is converted to one of its physiologically acceptable acid addition salts by treatment with an acid. |
| priorityDate | 1978-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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