| abstract |
New N-pyrrolyl-3-pyridazine-amines having a further aminic substituent in the 6 position of the formula (I),n wherein R, R 1 , R 2 and R 3 are hydrogen or lower alkyl, R 4 is e.g hydrogen or lower alkyl, R 5 and R 6 are e.g. lower alkyl or taken together with the adjacent nitrogen atom represent a saturated 5 - 6 membered heterocyclic ring which may contain a further heteroatom, R 7 and R 8 represent hydrogen or, taken together, a 1,3-butadienylene radical forming a benzo system fused with the pyridazine ring, for example N-2,5-dimethyl-1H-pyrrol-1-yl)- 6-morpholino-3-pyridazineamine or N-(2,5-dimethyl-1H-pyrrol- 1-yl)-4-(4-hydroxypiperidino)-1-phthalazineamine, and their pharmaceutically acceptable salts are made e.g. by contacting a hydrazino derivate of the formula (II), wherein the substituents have the same meaning as above or an acid addition salt thereof with a dicarbonyl compound of the formula (III), wherein the substituents have the same meaning as above, or a functional derivative thereof in the presence of an acid catalyst at a temperature between 15°C and 120°C. n The new compounds can be used as antihypertensive agents. |