http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0008888-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D477-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-568 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 |
| filingDate | 1979-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ce24f6c255f83ff842fac61bece0e93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a43bd92c853e81897d7cd8bbf07f1ebf |
| publicationDate | 1980-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0008888-A1 |
| titleOfInvention | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them |
| abstract | The compounds of the formula (II) :n and salts and esters thereof wherein R, is a lower alkyl group, an aralkyl group or is a lower alkyl group substituted on other than the carbon atom to which the sulphur atom is attached by a CO 2 R 3 , OR 4 , N(R 5 )COR 6 , N(R 5 )CO 2 R 6 or N(R 5 )R 7 group or by a C0 2 R 3 and a N(R 5 )COR 6 group wherein R 3 is a group such that CO 2 R 3 is a carboxylic acid group or a salt or lower alkyl or benzyl ester thereof; R 4 is a hydrogen atom or a lower alkyl, lower acyl, benzyloxycarbonyl or p-nitrobenzyloxycarbonyl group or a CONR 8 R 9 group, R 5 is a hydrogen atom or a lower alkyl group; R 6 is a lower alkyl, benzyl or p-nitrobenzyl group; R 7 is a hydrogen atom or a lower alkyl aralkyl, benzhydryl or trityl group; R 8 is a hydrogen atom or a lower alkyl or phenyl group; R 9 is a hydrogen atom or a lower alkyl group; and R 2 is a hydrogen atom or an azidoloweralkyl group or a group CR 10 R 11 R 12 wherein R 10 is a hydrogen atom or a hydroxyl group; R 11 is a hydrogen atom or a lower alkyl group; and R 12 is a hydrogen atom, loweracyloxyloweralkyl group, hydroxyloweralkyl group, tower alkyl group, a benzyl group, a phenyl group or is joined to R 11 to form part of a C 5-7 carbocylic ring or is a group of the formula CH(OH)R 13 or CHX wherein R 13 is a hydrogen atom or lower alkyl group and X is an oxygen atom or a CR 14 R 1 group where R 14 is a hydrogen atom or a lower alkyl, phenyl, CNCO 2 R 16 or COR 16 group where R 16 is lower alkyl, phenyl or benzyl group and R 15 is a hydrogen atom or a lower alkyl group or is joined to R 14 to form part of a C S . 7 carbocyclic ring; except all isomers of thienamycin and except compounds wherein R 2 is ethyl or 1-hydroxyethyl and R, is β-aminoethyl or β-acetamidoethyl and except compounds wherein R 2 is isopropyl and R 1 is trans β-acetamidoethyl, are antibacterials. Their preparation and their use in pharmaceutical compositions are described. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0011173-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0017992-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0024832-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0033209-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0061231-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0040408-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0126780-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101367830-B |
| priorityDate | 1978-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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