| abstract |
Compounds of the formula (I):n characterised in thatn n is 1 to 5; L is CO 2 R wherein R is hydrogen or CO z 2 is an ester group in which R contains from 1 to 12 carbon atoms, or CH 2 COR, wherein R, is C 1-4 alkyl; Y is -CH 2 CH 2 -, -CH=CH- or -C≡C-; R 2 is hydrogen or C 1-4 alkyl; R. is hydrogen or C 1-9 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-6 alkyl; or R 2 and R. taken with the carbon atom to which they are joined represent a C 5-8 cycloalkyl group; R 5 is NR 6 R, wherein R 6 and R 7 independently are hydrogen, C 1-4 alkyl, phenyl C 1-4 alkyl or NR 6 R 7 is a 3 to 7 membered heterocyclic group containing only one hetero atom; hydrogen, C 1-4 alkyl or C 1-4 alkyl substituted by an OH, C 1-4 alkoxy, CN, halogen or NR 6 R 7 group as defined above, or by one or two CO 2 A groups in which A is hydrogen or a group containing from 1 to 12 carbon atoms; and R 8 and R 9 independently are hydrogen, C 1-4 alkyl or together with the carbon atom to which they are joined are a C 3-6 cycloalkyl group; and salts thereof, having activities similar to but more selective than those of natural prostaglandins, a process for their preparation and pharmaceutical compositions containing them. |