| abstract |
The invention relates to new 3,20-dioxo 4,9-diene 21-hydroxyl steroid derivatives (1): in which X is a hydrogen or a tritium, R, an alkyl of 1 to 3 carbons, R 2 an alkyl of 1 to 12 carbons, R 3 an alkyl of 1 to 4 carbons, in the form of epimer 21R or 21S or of their mixtures, as well as their preparation process, their application as medicaments and the pharmaceutical compositions containing them.n n n Compounds I are endowed with remarkable progestomimetic and anti-estrogen activities. |