| abstract |
A compound of the formula (I):n wherein:n XisOorS; Y is-CH-CH-or-C≡C-; n is 1 to 5; R, is hydrogen or CO 2 R 1 represents an ester group in which the R, moiety contains from 1 to 12 carbon atoms; R 2 is hydrogen or C 1-4 alkyl; R 3 is hydroxy or protected hydroxy; R 4 is C 1-9 alkyl, C 3-8 cycloalkyl or C 3-8 cycloalky-C 1-6 alkyl; or R z and R 4 taken with the carbon atom to which they are joined represent a C 5-8 cycloalkyl group; and R s is C 1-6 alkyl substituted by one nitro, hydroxy, C 1-6 alkoxy, CO 2 A, (CO 2 A) 2 , CN or halogen group; C 5-8 cycloalkyl; or CO 2 A; in R 5 when present A is hydrogen or CO 2 A represents an ester group in which the A moiety contains from 1 to 12 carbon atoms; and salts thereof; has useful pharmaceutical activity, including bronchodilator activity. |