| abstract |
N-(Benzothienopyrazol)-amides of formula n<CHEM>n [in which R1 is methyl or ethyl; R2 is cyclohexyl, phenyl, 3-pyridyl, C2-5 haloalkyl, C3-5 alkoxyalkyl or n<CHEM>n (wherein R3 and R4 are hydrogen, methyl or ethyl; and R5 is hydrogen or C1-5 alkyl); and R6 is hydrogen, chlorine, fluorine, methyl, 6,7-methylenedioxy, 6,7-dimethoxy, 6,7-diacetoxy or -NR7R8 (wherein R7 and R8 are hydrogen, methyl or ethyl; with the provisos that (a) when R2 is cyclohexyl, then R6 is hydrogen methyl or ethyl, (b) when R2 is phenyl, then R6 is hydrogen, and (c) when R2 is 3-pyridyl, then R6 is hydrogen or fluorine] and pharmaceutically acceptable acid addition salts thereof. The compounds exhibit a strong antiviral activity. Pharmaceutical compositions containing the compounds are described and exemplified. |