| abstract |
6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-IH-3-benzazepines of formula:n in which:n R is a lower alkyl of 1-6 carbons; R, is hydrogen, benzyl, phenethyl, lower alkanoyl of 1-5 carbons, lower alkyl of 1-5 carbons, lower alkyenyl of 3-5 carbons, furyl methyl, thienylmethyl or phenacyl; R 2 and R 3 are each hydrogen, lower alkyl of 1-5 carbons, lower alkanoyl of 2-5 carbons, benzyl or, when taken together, methylene; and R 4 is hydrogen or one or two substituents from the group comprising trifluoromethyl, halo, methyl, methoxy, acetoxy, hydroxy or methylthio; or pharmaceutically acceptable, acid addition salts thereof nshow dopaminergic activity.n Intermediates and chemical methods for preparing them are described. An important species is 6-methyl-7,8-dihydroxy-l(p-hydroxyphenyl) -2,3,4,5- tetrahydro -1N-3- benzazepine, as the base or one of its salts, which has antihypertensive activity. |