| abstract |
Synthesis of 5-methoxy-psoralen of formula by methylation of phloroglucinol, cyclization of the monomethyl ether of phloroglucinol thus obtained with chloro acetonitrile, reduction of 6-hydroxy-4-methoxycoumaranone-3, cyclization of hydroxy-6-methoxy-4-coumaran with acrylonitrile and dehydrogenation of 3,4,4 ', 5'-methoxy-5 psoralen tetrahydro.n n n Application of 5-methoxy-proralene for the treatment of psoriasis. |