http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EC-SP982491-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 |
| filingDate | 1998-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59887c996d65c9413255f053b7b1f624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de4cc49b3ccfd02f9d75aeef962f6675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f3b08128c18a34e7a54add15d9544f6 |
| publicationDate | 1999-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EC-SP982491-A |
| titleOfInvention | COMPOUNDS |
| abstract | Compounds of formula I (graph), in which: R1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, ttrifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-4alkyl, C1-4alkoxy, C1-4 aryl-alkoxy, C1-4alkylthio, C1-4alkoxy C1-4alkyl, C3- cycloalkyl group 6-C1-4alkoxy, C1-4alkanoyl, C1-4alkoxycarbonyl, C1-4alkylsulfonyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl-C1-4alkyl, C1-4alkyl-sulfonamido, C1-4alkyl-amido, alkyl C1-4-sulfonamido C1-4-alkyl, C1-4-alkyl-amido-C1-4-alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamido-C1-4-alkyl, arylcarboxamido-C1-4-alkyl, aroyl, aroyl-C1-4-alkyl, or aryl- C1-4 alkanoyl; a group R3OCO (CH2) p, R3CON (R4) (CH2) p, R3R4NCO (CH2) p or R3R4NSO2 (CH2) p, where each of R3 and R4 independently represents a hydrogen atom or a C1-4 alkyl group, or R3R4 is part of a C3-6 azacycloalkane or (2-oxo) azacycloalkane C3-6 ring, and p represents zero or an integer from 1 to 4; or an Ar3-Z group, in which Ar3 represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered heterocyclic aromatic ring, and Z represents a bond, O, S or CH2; R2 represents a hydrogen atom or a C1-4 alkyl group: q is 1 or 2: A represents a group of the formula (a), (b) or (c): (graph), in which Ar represents an optionally substituted phenyl ring or a ring optionally substituted 5- or 6-membered heterocyclic aromatic or an optionally substituted bicyclic ring system; Ar1 and Ar2 each independently represent an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered heterocyclic aromatic ring; and Y represents a bond -NHCO-, -CONH-, -CH2-, or - (CH2) mY 1 (CH2) n-, in which Y1 represents O, S, SO2 or CO, and m and n each represent zero or 1 , such that the sum of m + n is zero or 1: with the proviso that, when A represents a group of formula (a), any substituent present in Ar in ortho position with respect to the carboxamide moiety is necessarily a hydrogen atom or a methoxy group; and its salts. The compounds of formula (I) and their salts have an affinity for dopamine receptors, in particular the D3 receptor, and therefore potential in the treatment of conditions where modulation of the D3 receptor is beneficial, eg. as antipsychotic agents. |
| priorityDate | 1998-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.