http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EC-SP10010719-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5d62b24bd9ee041f521ff3177003b86 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-26 |
| filingDate | 2010-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8b25b76d3243afb94fdb09a01edddd5 |
| publicationDate | 2011-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EC-SP10010719-A |
| titleOfInvention | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
| abstract | The present invention relates to the synthesis of a new 1,1-dimethylbiguanid glycinate salt, called Metformin glycinate designed for the control of blood glucose. This salt exhibits advantages over other metformin salts. These advantages refer, first of all, to the fact that the counterion exhibits hypoglycemic effects on their own, the hypoglycemic effect is more pronounced. In addition, this salt exhibits a better absorption, reaching a higher plasma concentration than that produced with metfromine hydrochloride. The synthesis was carried out from metformin hydrochloride releasing the hydrochloride counterion, using an ion exchange column, the released metformin was dissolved in aqueous medium and subsequently glycine was added at room temperature and constant stirring, the resulting product was heated producing a concentrated solution of the product, an organic solvent is added to create insolubility and promote crystallization in a saturated medium, the excess glycine precipitates and the methaphromine glycinate salt is obtained after filtering and concentrating said salt. Metformin glycinate salt has a more pronounced pharmacological effect in reducing blood glucose levels. |
| priorityDate | 2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.