| abstract |
The present invention relates to a fixed oral dose pharmaceutical combination, which comprises: a) a therapeutically effective amount of Alisquirene, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Valsartan, or a pharmaceutically acceptable salt of same, wherein the fixed oral dose pharmaceutical combination shows an in vitro solution of component a) of 80 percent or less after 10 minutes, and 98 percent or less after 20 minutes, and a dissolution profile of the component b) 25 percent or more after 30 minutes, and 40 percent or more after 60 minutes, at a pH of 4.5. |