http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EC-SP088367-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba1303ccef7c3a8ed8a6de0cf7459278 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-04 |
| filingDate | 2008-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d6d4cb221f7e0d3c6cc3cd092c30293 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8018518f1d023b1a9b19431f5641366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60e707cd5f3460141932741e44a48c6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_204b5db890c2d264a6a439ddd88c167e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d60024b902428e2e3dc0f2c4a13b2187 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd2cf7f8b58cee6a943c338b451649da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_804fa2a558795e3e3e8953f5afe0fa88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33bde13724a5b82bac8ab04267365211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b5058129b9fe66ec9cb9bf4bf548c0b |
| publicationDate | 2008-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EC-SP088367-A |
| titleOfInvention | DERIVATIVES OF BIFENYL AND ITS USE IN THE TREATMENT OF HEPATITIS C |
| abstract | A compound that is a biphenyl derivative of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is a C1-C6 alkyl group or a -A1, -L1-A1, -A1-A1 /, -L1-A1-A1 /, -A1-L1-A1 /, -A1-Y1-A1 /, -A1-Het1-A1 /, -L1-A1-Y1-A1 /, -L1-A1-Het1-A1 /, -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1 /, -A1-Y1-Het1 -A1 /, -A1-Het1-Y1-A1 /, -A1-Het1-L1-A1 /, -A1-L1-Het1-A1 / or -L1-Het1-L1 /; - A and B are the same or different and each represents a direct link or a half -CO-NR / -, -NR / -CO-, -NR / -CO2-, -CO-, -NR / -CO-NR // -, -NR / -S (O) 2-, -S (O) 2-NR / -, -SO2-, -NR / -, -NR / -CO-CO-, -CO-O-, -O-CO-, - (C1-C2 alkylene) -NR / - or - (C1-C2 hydroxyalkylene) -NR / -, where R / and R // are the same or different and each represents hydrogen or C1 alkyl -C4; - R2 and R3 are the same or different and each represents C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or halogen; n and m are the same or different and each represents 0 or 1; R4 is a C1-C6 alkyl group or a half -A4, -L4-A4, -A4-A4 /, -L4-A4-A4 /, -A4-L4-A4 /, -A4-Y4-A4 /, - A4-Het4-A4 /, -L4-A4-Y4-A4 /, -L4-A4-Het4-A4 /, -L4-Het4-A4, -L4-Y4-A4, -L4-Y4-Het4-A4, -L4-Het4-Y4-A4, -L4-Y4-Het4-L4 /, -A4-Y4-Het4-A4 /, -A4-Het4-Y4-A4 /, -A4-Het4-L4-A4 /, - A4-L4-Het4-A4 / or -L4-Het4-L4 /, each A1, A4, A1 / and A4 / are the same or different and represent a phenyl, 5 to 10 membered heteroaryl, 5 to 10 membered heterocyclic moiety or C3-C8 carbocyclyl; each L1 and L4 are the same or different and represent a C1-C4 alkylene or C1-C4 hydroxyalkylene group; each Y1 and Y4 are the same or different and represent -CO-, -SO- or -S (O) 2-; each L1 / and L4 / are the same or different and represent hydrogen or a C1-C4 alkyl group; and each Het1 and Het4 are the same or different and represent -O-, -S- or -NR / -, where R / is hydrogen or a C1-C4 alkyl group, the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties being in R1 and R4 optionally fused to a phenyl, 5-10 membered heteroaryl or 5-10 membered heterocyclyl ring; and the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties at R1 and R4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from - (C1-C4 alkyl) -X1, -CO2R /, -SO2NR / R // , -S (O) 2-R /, -CONR / R //, -NR / -CO-R ///, -NR / -S (O) 2-R ///, -CO-NR / - (C1-C4 alkyl) -NR / R // and -CO-O- (C1-C4 alkyl) -NR / R // and / or (b) 1, 2 or 3 unsubstituted substituents selected from - (C1 alkyl -C4) -X2, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 hydroxyalkyl, hydroxy, cyano, nitro and -NR / R //, where X1 is -CO2R /, -SO2-R /, -NR / -CO2-R //, -NR / -S (O) 2-R ///, -CONR / R // or -SO2-NR / R // , each X2 is the same or different and is cyano, nitro or -NR / R //, each R / and R // are the same or different and represent hydrogen or C1-C4 alkyl and each R /// is the same or different and represents C1-C4 alkyl. |
| priorityDate | 2005-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.