| abstract |
The present invention provides a compound of Formula I. This compound is an aldosterone synthase and aromatase inhibitor, and therefore can be used for the treatment of a disorder or a disease mediated by aldosterone synthase or For aromatase. In accordance with the above, the compound of Formula I can be used in the treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, kidney disease, post-myocardial infarction, coronary heart disease, inflammation, increased collagen formation, fibrosis, such as cardiac or myocardial fibrosis, and remodeling followed by hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, uterine hemorrhage dysfunctional, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer, and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition. |