| abstract |
The present invention relates to N-heterocycle substituted derivatives, compositions containing these derivatives and methods of their use for the prevention and treatment of conditions relieved by the absorption of monoamine, including, inter alia, vasomotor symptoms (SVM), sexual dysfunction , gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromilagia syndrome, nervous system disorders and combinations thereof, particularly those conditions selected from the group consisting of the greatest depressive disorder, vasomotor symptoms, stress and urinary impulse incontinence, fibromyalgia, pain, diabetic neuropathy and combinations thereof. Where: A is phenyl, naphthyl, thiophenyl, pyridinyl, furanyl, benzofuranyl, isobenzofuranyl, xanthenyl, pyrrolyl, indolizinyl, isoindolyl, indolyl or benzothiophenyl, where 1 to 3 carbon atoms of said A is optionally replaced with a nitrogen atom . U is N or O; W is H or OR8; the other substituents are defined in the claims |