abstract |
This invention relates to certain benzimidazole and pyrimidazole derivatives which adhere with high selectivity and / or high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions containing said compounds and the use of said compounds in the treatment. of diseases of the central nervous system (CNS) .This invention also relates to the use of these benzimidazole and pyrimidazole derivatives in combination with one or more other CNS agents that enhance the effects of the other CNS agents: Additionally, this invention relates to use of said compounds as probes for the location of GABAA receptors in tissue sections |