| abstract |
Compounds having the structural formula I or one of them pharmaceutically acceptable, in which R is optionally substituted phenyl, cycloalkenyl or heteroaryl X is alkylene or C (O) CH2 Y is N (R2) CH2 CH2 (R3) -, - OCH2 CH2 N (R2) -, -0-, -S-, -ch2s-, - (ch2 (2-NH-, or optionally substituted, - (graph) - r m and n are 2-3, and- Q is nitrogen or optionally substituted carbon; Z is optionally substituted phenyl, phenyl, phenylalkyl or heteroaryl, diphenylmethyl (graph) R6_ C (0 = -, R6_SO2-, R6-0C (o) -, R7- N (R8) -C (0) -, R7- N (R8) -C (S) -, phenyl- CH (OH) -, or phenyl- C - (= NOR2) -; 0 when Q is CH, phenylamino or pyridylamino; 0 Z and Y together are substituted piperidinyl or substituted phenyl; and R2, R3, R6, R7, and R8 are as defined herein, and their use for the treatment of Parkinson's disease, alone or in combination with other agents to treat the disease of Parkinson, and the pharmaceutical compositions comprising them; and also described n a process for preparing intermediate useful for preparing compounds of formula I. |