| abstract |
A composition for solid oral dose of extended release coated with a film containing a nasal decongestant, pseudoephedrine, or its salt, for example, pseudoephedrine sulfate in an effective core is described as providing a geometric maximum plasma concentration of pseudoephedrine between about 345 ng / ml in a time between about 7.60 hours and about 8.40 hours and having two or three film coatings on the core, the second contains an amount of antihistamine, non-sedative, desloratadine, effective as to provide a maximum geometric plasma concentration of desloratadine between about 2.15 ng / ml and about 2.45 ng / ml in a time between about 4.0 hours and about 4.5 hours, and the use of the composition to treat patients who show signs and symptoms associated with allergic and / or inflammatory conditions of the skin and airways. |