| abstract |
Compounds of the formula in which R1, R2 and R3 are as defined above, which are inhibitors of deprotein kinase enzymes such as Janus Kinase 3 and which, as such are, therapeutic agents useful as immunosuppressive agents for organ transplants, xenotransplantation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, type I diabetes and complications due to diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's diseases, Alzheimer's disease, leukemia and other autoimmune diseases. |