| abstract |
The present invention relates to new methods for producing compounds useful as soluble guanylate cyclase (sGC) stimulants. These methods lend themselves to large-scale production and give stable 3- (2-pyrimidinyl) pyrazoles of formula I, including compound I, compound IA and compound IB, in high purity and yields. The present invention has the additional advantage of simple reaction conditions that can be scaled for large-scale production. The invention also provides novel intermediates useful in the preparation of said compounds. |