http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-201900246-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G2650-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2609 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-08 |
| filingDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-201900246-A1 |
| titleOfInvention | INHIBITOR OF ATF-DEPENDENT CELL REVERSE TRANSPORTERS AND METHOD FOR ITS PRODUCTION |
| abstract | The invention relates to the chemistry of drug compounds, in particular to a group of chiral conjugates (optically active hybrid molecules) of oligoester polyol nature, which are inhibitors of ATP-dependent inverse cell transporters (OEP inhibitor). An OEP inhibitor is a conjugate with an equimolar ratio of optically active polyoxypropylenehexol and polyoxypropylene glycol. The claimed method according to which the conjugate is obtained provides the possibility of obtaining a drug that increases the effectiveness of drugs by inhibiting the mechanisms of multiple drug resistance of cells. The resulting preparation can be used in the field of biology, pharmacology, pharmaceuticals, medicine, agriculture. An OEP inhibitor is obtained by oxypropylation of a mixture of sorbitol and a bifunctional oxygen-containing compound in the presence of an alkali or alkaline earth metal hydroxide. The bifunctional oxygen-containing compound may be water, propylene glycol, dipropylene glycol, tripropylene glycol, tetrapropylene glycol, pentapropylene glycol, hexapropylene glycol, heptapropylene glycol, or a mixture thereof. The inhibitor is a conjugate of polyoxypropylene glycol with a molecular weight of from 300 to 500 Da and polyoxypropylenehexol with a molecular weight of from 1000 to 1500 Da in an equimolar ratio, with a hydroxyl number in the range of 215-240 mg KOH / g. |
| priorityDate | 2016-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.