http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-201890969-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 |
| filingDate | 2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-201890969-A1 |
| titleOfInvention | IMPROVED METHOD FOR OBTAINING SULPHATED HA OF HIGH DEGREE OF PURITY |
| abstract | The present invention relates to an improved method for producing sulfated hyaluronic acid (HA), sulfated HA derivatives and / or their mixtures characterized by high purity and sulfatization ranging from 1 to 3, which includes the following stages: a) HA solubilization Na or HA-derivative-Na in an aprotic solvent in the presence of an organic sulfonic acid; b) sulphating the resulting solution by adding an excess of sulphating agent; c) precipitation in ethanol to obtain a precipitate; d) solubilization of the resulting precipitate in a mixture of water and an aprotic solvent used in step a) in the presence of an excess of NaCl with pH adjustment within the range from 3 to 4; e) additional precipitation with ethanol to obtain a powder; f) washing the powder resulting from the implementation of stage e), and drying the resulting product under vacuum. The present invention also relates to the sulfated HA thus obtained, the sulfated HA derivative and / or mixtures thereof having a high degree of purity and a degree of sulfation ranging from 1 to 3, and the corresponding pharmaceutical mixtures. |
| priorityDate | 2015-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.