| abstract |
The invention presents a new method for the production of material for bone regeneration, in which biodegradable fiber, including PLGA, contains calcium phosphate particles, using electrospinning with commercial efficiency, as well as a new material for bone regeneration produced by this method. Biodegradable fiber, in which small particles of calcium phosphate are dispersed, essentially evenly in the biodegradable fiber, is produced by heating the PLGA resin in a plasticizer to soften it to a viscosity of 10-10Pa s; mixing the powder of small particles of calcium phosphate with a softened PLGA resin by feeding the powder into the plasticizer while rotating the blade of the plasticizer; rotating the plasticizer blade with continuous force when heated to mix the mixture so that thermal and mechanical energy is applied to the mixture to grind aggregates of small particles of calcium phosphate, and thereby prepare a composite of PLGA resin and dispersed in it small particles of calcium phosphate; dissolving this composite with a solvent and mixing for a predetermined time to obtain a dope in which the PLGA resin is completely dissolved in the solvent, and small particles of calcium phosphate are dispersed without aggregation in the solvent in which the PLGA resin is dissolved; and electrospinning this spinning dope. |