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filingDate 2017-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EA-201792364-A1
titleOfInvention PLASMID DNA ENCODING BETA ENDORFIN, BACTERIAL PRODUCER, ANALGETIC MEANS
abstract The invention relates to the field of medicine, pharmacology, biotechnology, molecular biology, genetic engineering and can be used for analgesia. Plasmid DNA for transient expression in mammalian cells is proposed, represented by a skeleton containing prokaryotic and eukaryotic elements, as well as a fragment providing enhanced capture of plasmid DNA by the cells, and a polynucleotide encoding beta-endorphin, modified to increase receptor receptor, optimized by a code on a code that is optimized by a code that is optimized by a code and a code that is optimized by a code and a beta endorphin, that is modified by a code and an endotropy to the receptor, optimized by the code for beta-endorphin. for expression in mammalian cells. Also proposed is a producer of such a plasmid DNA based on a bacterial cell and an analgesic agent for use in mammals, in particular humans, based on it. The technical result from the use of the developed plasmid DNA and an analgesic based on it is to increase the controllability of beta-endorphin synthesis, to increase the efficiency of plasmid DNA with which beta-endorphin is synthesized, and to reduce its amount to achieve analgesia, to increase the duration of analgesia and to expand spectrum of analgesic drugs.
priorityDate 2017-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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