| abstract |
The invention provides a potassium-competitive acid blocker (P-CAB) for use in treating, preventing and / or reducing the symptoms of gastroesophageal reflux disease (GERD) in patients who have partially responded to treatment with a proton pump inhibitor (PPI). P-CAB can be selected, for example, from 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamine (vonoprazan), revaprazan (YH1855 ), YH4808, RQ-4 and CS-526 or their salts. |