| titleOfInvention |
SUBSTITUTED DERIVATIVES 4,5,6,7-TETRAHYDROPYRAZOLO [1,5-α] PYRAZINE AND DERIVATIVES 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO [1,5-α] [1,4] DIAZEPIN AS AN INHIBITORS ROS1 |
| abstract |
The invention relates to substituted derivatives of 4,5,6,7-tetrahydropyrazolo [1,5-α] pyrazine and derived 5,6,7,8-tetrahydro-4H-pyrazolo [1,5-α] [1,4 ] diazepine formula (I), where the variables have the meaning defined in the claims. The compounds of the present invention are useful as inhibitors of ROS1. The present invention also relates to methods for producing such new compounds, to pharmaceutical compositions containing said compounds as an active ingredient, as well as to the use of said compounds as a medicine. |