| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C53-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate |
2015-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2017-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-201691538-A1 |
| titleOfInvention |
METHOD OF OBTAINING VORTIOXETHINE SALTS |
| abstract |
The invention relates to an improved process for the preparation of pharmaceutically active ingredients and also to high-purity salts and pharmaceutical compositions obtained using this method. In particular, the invention relates to an economically advantageous method for the preparation of a compound having an international non-proprietary name (INN) vortioxetine and the chemical name of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine. Vortioxetine corresponds to the following formula I. In particular, the invention relates to the preparation of a high-purity vortioxetine L - (+) - mandelate salt of formula IX, the conversion of this salt to other salts of high purity and also to the formulation of these salts. |
| priorityDate |
2014-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |