| abstract |
The present invention relates to methods and intermediate compounds for the manufacture of {1- {1- [3-fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4-yl} -3- [4- (7H-pyrrolo [2,3-d ] pyrimidin-4-yl) -1H-pyrazol-1-yl] azetidin-3-yl} acetonitrile, useful in the treatment of diseases associated with the activity of Janus kinase (JAK), including inflammatory diseases, autoimmune diseases, cancer, and other diseases . |