| abstract |
The invention describes thiazolecarboxamide and pyridinecarboxamide derivatives of formula (I), or pharmaceutically acceptable salts thereof, wherein X is C or N; A, B and D are rings; a bond is a normalized bond in an aromatic ring containing both N and X, which formally is a C = C bond, when X is C, and a single bond when X is N; ring A has the formula (A-1) or (A-2), where E1 and E2 are rings; their compositions and methods of use. The compounds inhibit the activity of Pim-kinases and are effective in treating diseases associated with the activity of Pim-kinases, including, for example, cancer and other diseases. |