| abstract |
The present invention relates to certain sulfonyl and hydroxy derivatives of acetic acid and to methods for their synthesis. This invention also relates to pharmacological compositions containing the compounds of the present invention, and to methods for treating asthma, rheumatoid arthritis, COPD (chronic obstructive pulmonary disease), rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye syndrome, neointima proliferation, which leads to restenosis and coronary heart failure, stroke, hepatic diseases, tumor metastasis, as well as other inflammatory disorders characterized by overexpression and hyperactivation of matrix metalloproteinase, using these compounds. |