http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-201301170-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-34 |
| filingDate | 2012-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-201301170-A1 |
| titleOfInvention | IMPROVED METHOD FOR OBTAINING RILPIVIRIN |
| abstract | The present invention relates to the preparation of a key intermediate for rilpivirin, namely (E) -4- (2-cyanoethenyl) -2,6-dimethylphenylamine (II) hydrochloride, by a process involving the interaction of the tetrafluoroborate salt of a diazonium ion 2,6-dimethyl-4- amino-1-carboxybenzylphenylamine (VI) with acrylonitrile in the presence of palladium acetate, followed by acid conversion and its subsequent conversion to the hydrochloride (II) salt, while the undesired Z isomer has less than 0.5%, which gives rilpivirine hydrochloride having less than 0, 1% isomer Z. |
| priorityDate | 2011-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.