| abstract |
The invention relates to new pyrrolidine derivatives of formula (I), where R, R and R are as defined herein, as glutaminyl cyclase inhibitors (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues in pyroglutamic acid (5-oxoprolyl, pGlu *) with ammonia cleavage, and the intramolecular cyclization of N-terminal glutamate residues in pyroglutamic acid with cleavage of water. |